2021 MEETING

The ABX Winter 2021 Virtual Meeting

 The second ABX meeting was held over Zoom on the 17th December 2021.

Originally planned to be a “blended” meeting (both in person and virtually) we decided, given the situation regarding the COVID-19 pandemic and Omicron infections, to host the meeting in a fully virtual format. 

This decision was made in the interest and safety of all members, and fortunately the meeting proved to be a great success!

We are looking forward to the next meeting, to continue highlighting the scope of collaborative potential within the world of antibiotic discovery in the UK, and beyond.

Presentations

 

The presentations from the meeting are available to view below. For more information on each speaker, click on the titles in the programme to go to the YouTube link. The flash talks provide researchers with an opportunity to briefly showcase their work.

Poster Presentations

 

Menaka Menikpurage                                             Kudzai Hwengwere

ABX Winter Meeting Programme 2021

 

 

Friday 17th December 2021

 

10:00 - 10:10     

Introduction

Professor Mat Upton

Professor of Medical Microbiology – University of Plymouth

 

10:10 - 10:20     

Eliciting antimicrobial production using low level antibiotics

Dr Amy McLeman

Postdoctoral Research Associate – Liverpool School of Tropical Medicine

 

10:20 - 10:30     

Old drug with new (re)purposes: Thioridazine as a new effective antimicrobial

Dr Daniela Alves Ferreira

Postdoctoral Fellow – Trinity College Dublin

 

10:30 - 10:50     

Antibiotics: New approaches required to address a failed market and failing research landscape?

Professor Chris Dowson

Professor of Microbiology – University of Warwick

 

10:50 - 11:00     

Flash talks:

Applying droplet fluidics for tuberculosis drug discovery

Antonia Molloy

PhD Student – Aston University

 

The discovery and characterisation of antimicrobials that enhance pyrazinamide activity against Mycobacterium tuberculosis

Eleanor Porges

PhD Student – UK Health Security Agency

 

Molecular mechanisms of spirotetronate antibiotic biosynthesis

Rebecca Clayton

PhD Student – The University of Warwick

 

11:00 - 11:05     

Break

 

11:05 - 11:15     

A switch in focus: targeting AcrA dynamics to inhibit the AcrAB-TolC multidrug efflux pump

Benjamin Lewis

PhD student – King's College London

 

11:15 - 11:25     

Altering adeABC Antibiotic Sensitivity Response with Quadruplex DNA

Chisom Meludu

PhD Candidate - Anglia Ruskin University

 

11:25 - 11:35     

Defining the role of efflux in bacterial biofilm formation and antimicrobial resistance to develop new treatments for infection

Vicky Bennett

PhD student - University of Bath

 

11:35 - 11:45     

In vitro efficacy of relebactam versus avibactam against Mycobacterium abscessus complex

Dr James Harrison

Postdoctoral Researcher– Aston University

 

11:45 - 11:55     

Antimicrobial resistance associated with Northern Irish calf houses

Katie Lawther

PhD student – Queen's University Belfast

 

11:55 - 12:05     

Flash talks:

Investigation into bacterial siderophores and their uses as novel therapeutics

Alazhar Colombowala

Research Assistant – Anglia Ruskin University

 

Innate Immune Factors as Antibiotic Replacements

Rushiil Ravichandran

IRC Enterprise Partnership Scholar – Trinity College Dublin

 

Macrophage-induced persisters; developing a scaffold for testing novel compounds against phenotypically resistant Mycobacterium tuberculosis

Suzie-Hingley-Wilson

Lecturer in Bacteriology – University of Surrey

 

12:05 - 12:10     

Break

 

12:10 - 12:20     

Marine natural products as a source of new or novel antimicrobials – investigating hosts and microbial symbionts as producers

Dr Grant Garren January

Research Fellow – University of Plymouth

 

12:20 - 12:30     

Marine derived Streptomyces microflavus producing antimicrobial compounds active against Gram positive pathogens

Jazz Conway

PhD Student – University of Plymouth

 

12:30 - 12:40     

High-throughput approaches to chemotype and phenotype Pseudomonas aeruginosa (and other bacteria)

Hannah Doherty

PhD student – University of Birmingham

 

12:40 - 12:50     

Prevalence of multidrug resistance in Pseudomonas spp. Isolated from wild bird faeces in an urban aquatic environment

Dr Caray Walker

Senior Lecturer in Microbiology – Anglia Ruskin University

 

12:50 - 13:00     

Flash talks:

Using Microbiome-derived antimicrobials to treat Acinetobacter baumannii

Peter Alexander

Postgraduate Research Student – Queen's University Belfast

 

Mapping Antarctic Marine Biodiversity: the diversity of microbes and antimicrobial discovery

Kudzai Hwengwere

PhD Candidate – Anglia Ruskin University, University of Plymouth, and British Antarctic Survey

 

13:00 - 13:30     

Lunch

 

13:30 - 13:40     

Developing novel antibacterial agents targeting bacterial DNA gyrase

Professor Tony Maxwell

Group Leader – John Innes Centre

 

13:40 - 13:50     

Chemoenzymatic synthesis of NDP sugars as chemical biology tools to explore the GDP-D-mannose dehydrogenase from Pseudomonas aeruginosa

Professor Gavin Miller

Professor of Biological Chemistry – Keele University

 

13:50 - 14:00     

Antimicrobial efficacy of XF-73 against Gram-positive microorganisms 

Isabella Romeo-Melody

PhD Student – Aston University

 

14:00 - 14:30     

(New) Pathways to antibiotic approval: Implications for R&D 

Dr John Rex

Editor-in-Chief  – AMR Solutions

 

14:30 - 14:45     

Questions

 

14:45 - 16:00     

Discussion to end

 

16:00                    

Finish